Association Study of BIF-1 Gene Expression with Histopathological Characteristics and Hormone Receptors in Breast Cancer

Abstract
Breast cancer (BC) is a heterogeneous disease that has different clinical outcomes. Bax-interacting Factor-1 (BIF-1) is a member of the endophilin B family that produces the pro-apoptotic BCL2-Associated X (BAX) protein in response to apoptotic signals. Lack of BIF-1 inhibits the intrinsic pathway of apoptosis and increases the risk of tumor genesis. The aim of the present study was to investigate the relationship between hormone receptors (ER, PR, HER2) status and different levels of BIF-1 gene expression in breast cancer patients.

Author
Kazhaleh Mohammadi, Mahdiyeh Salimi, S. Abdolhamid Angaji, Arthur Saniotis, Foroozandeh Mahjoobi

DOI
https://doi.org/10.21203/rs.3.rs-1038299/v1

ISSN

Publish Date: 2021-12-17