Bacterial Profile and Antimicrobial Resistance of Infections Among Hospitalized Burn Patients in Asia: A Systematic Review

Abstract
Burn injuries cause a considered number of deaths, mainly due to infections. Many\r\nlow and middle-income countries in Asia lack data on the causes of burn infections\r\nand their antimicrobials susceptibility patterns. This systematic review was conducted\r\nto analyze Asian studies on the main agents of infection among hospitalized burn\r\npatients and their antimicrobials resistance to guide the empirical treatment which is\r\nvery important for nosocomial infection control.\r\nA literature search was performed in electronic databases to identify related studies\r\nbetween 2013 and 2022. All the finding studies were screened to ensure compliance\r\nwith including criteria.\r\nAfter the full screening of the articles, 24 studies were included in this work. The\r\nmajority of pathogens were gram-negative bacteria (63.5%). The pooled prevalence of\r\nisolated bacteria of burn infection revealed that A. baumannii (23.8%), P. aeruginosa\r\n(20%), S. aureus (19.7%), and K. pneumoniae (11.5%) were the most frequent.\r\nAccording to the pooled results of Antimicrobial Susceptibility Testing (AST) of the\r\nincluded studies, most strains of isolated bacteria were multidrug-resistant (MDR). For\r\ngram-negative bacteria, the susceptibility pattern varies greatly according to the\r\ngenus. The levofloxacin is the only common effective antimicrobial in different\r\npercentages. Methicillin-resistant Staphylococcus aureus (MRSA) accounted for\r\n70.4% of the isolated S. aureus. Vancomycin and linezolid have a high susceptibility\r\nfor all gram-positive cocci.\r\nThis review suggests that the empirical therapy of hospitalized burn patients in Asia\r\nshould depend on the combination of antimicrobials that include levofloxacin to\r\nprevent increasing MDR emergence in the future. Further studies should be\r\nconducted to confirm the clinical effect of these procedures.

Author
Zean Zefenkey, Salah Mahdi Al-Bader , Hama Tellawi

DOI
https://doi.org/10.21271/ZJPAS.36.1.2

Publisher
Zanco Journal of Pure and Applied Sciences

ISSN
2412-3986

Publish Date: